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HMGB1 promotes differentiation syndrome by inducing hyperinflammation via MEK/ERK signaling in acute promyelocytic leukemia cells

Differentiation therapy based on all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) for the treatment of acute promyelocytic leukemia (APL) is complicated by the development of differentiation syndrome (DS), which can be fatal. We examined the role of HMGB1 (high-mobility group box 1) in DS u...

詳細記述

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書誌詳細
出版年:Oncotarget
主要な著者: Tang, Lanlan, Chai, Wenwen, Ye, Fanghua, Yu, Yan, Cao, Lizhi, Yang, Minghua, Xie, Min, Yang, Liangchun
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5432337/
https://ncbi.nlm.nih.gov/pubmed/28404891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15432
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