Direct Repression of FLIP Expression by c-myc Is a Major Determinant of TRAIL Sensitivity

Tumor necrosis factor alpha (TNF-α)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF-α family of death receptor ligands and holds great therapeutic potential as a tumor cell-specific cytotoxic agent. Using a panel of established tumor cell lines and normal cells, we found a significa...

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Autores principales: Ricci, M. Stacey, Jin, Zhaoyu, Dews, Michael, Yu, Duonan, Thomas-Tikhonenko, Andrei, Dicker, David T., El-Deiry, Wafik S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC516765/
https://ncbi.nlm.nih.gov/pubmed/15367674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.19.8541-8555.2004
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