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The Deubiquitinase Inhibitor PR-619 Sensitizes Normal Human Fibroblasts to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-mediated Cell Death

TNF-related apoptosis-inducing ligand (TRAIL) is a potential cancer therapy that selectively targets cancer cell death while non-malignant cells remain viable. Using a panel of normal human fibroblasts, we characterized molecular differences in human foreskin fibroblasts and WI-38 TRAIL-resistant ce...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Crowder, Roslyn N., Dicker, David T., El-Deiry, Wafik S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786729/
https://ncbi.nlm.nih.gov/pubmed/26757822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.713545
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