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Distinct Signaling Pathways in TRAIL- versus Tumor Necrosis Factor-Induced Apoptosis
Trimeric tumor necrosis factor (TNF) binding leads to recruitment of TRADD to TNFR1. In current models, TRADD recruits RIP, TRAF2, and FADD to activate NF-κB, Jun N-terminal protein kinase (JNK), and apoptosis. Using stable short-hairpin RNA (shRNA) knockdown (KD) cells targeting these adaptors, TNF...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1636728/ https://ncbi.nlm.nih.gov/pubmed/16940186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00257-06 |
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