NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing

Natural killer (NK) cell activation triggers sequential cellular events leading to destruction of diseased cells. We previously identified lytic granule convergence, a dynein- and integrin signal–dependent movement of lysosome-related organelles to the microtubule-organizing center, as an early step...

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Dettagli Bibliografici
Pubblicato in:J Cell Biol
Autori principali: Hsu, Hsiang-Ting, Mace, Emily M., Carisey, Alexandre F., Viswanath, Dixita I., Christakou, Athanasia E., Wiklund, Martin, Önfelt, Björn, Orange, Jordan S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2016
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5166499/
https://ncbi.nlm.nih.gov/pubmed/27903610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201604136
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