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WIP is essential for lytic granule polarization and NK cell cytotoxicity

Natural killer (NK) cells play important roles in host immunity by killing virus-infected and tumor cells. Killing of the target cell is achieved by formation of an immune synapse and localized secretion of lytic granules containing perforin and granzymes. Here, we demonstrate that Wiskott–Aldrich s...

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Hlavní autoři: Krzewski, Konrad, Chen, Xi, Strominger, Jack L.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268177/
https://ncbi.nlm.nih.gov/pubmed/18258743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711593105
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