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CD28-stimulated ERK2 phosphorylation is required for polarization of the microtubule organizing center and granules in YTS NK cells

Activation of natural killer (NK) cell cytotoxicity requires adhesion and formation of a conjugate with a susceptible target cell, followed by actin polymerization, and polarization of the microtubule organizing center (MTOC) and cytolytic granules to the NK cell immune synapse. Here, by using the Y...

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Detalhes bibliográficos
Main Authors: Chen, Xi, Allan, David S. J., Krzewski, Konrad, Ge, Baoxue, Kopcow, Hernan, Strominger, Jack L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1502460/
https://ncbi.nlm.nih.gov/pubmed/16801532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604236103
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