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Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase
The active RNA-dependent RNA polymerase of poliovirus, 3D(pol), is generated by cleavage of the 3CD(pro) precursor protein, a protease that has no polymerase activity despite containing the entire polymerase domain. By intentionally disrupting a known and persistent crystal packing interaction, we h...
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| Udgivet i: | EMBO J |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC516629/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15306852/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600357 |
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