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Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase
The active RNA-dependent RNA polymerase of poliovirus, 3D(pol), is generated by cleavage of the 3CD(pro) precursor protein, a protease that has no polymerase activity despite containing the entire polymerase domain. By intentionally disrupting a known and persistent crystal packing interaction, we h...
Gorde:
| Egile Nagusiak: | , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2004
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC516629/ https://ncbi.nlm.nih.gov/pubmed/15306852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600357 |
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