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Structural basis for proteolysis-dependent activation of the poliovirus RNA-dependent RNA polymerase

The active RNA-dependent RNA polymerase of poliovirus, 3D(pol), is generated by cleavage of the 3CD(pro) precursor protein, a protease that has no polymerase activity despite containing the entire polymerase domain. By intentionally disrupting a known and persistent crystal packing interaction, we h...

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Autors principals: Thompson, Aaron A, Peersen, Olve B
Format: Artigo
Idioma:Inglês
Publicat: 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC516629/
https://ncbi.nlm.nih.gov/pubmed/15306852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600357
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