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High-throughput Screening Identification of Poliovirus RNA-dependent RNA Polymerase Inhibitors

Viral RNA-dependent RNA polymerase (RdRP) enzymes are essential for the replication of positive-strand RNA viruses and established targets for the development of selective antiviral therapeutics. In this work we have carried out a high-throughput screen of 154,267 compounds to identify poliovirus po...

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Autors principals: Campagnola, Grace, Gong, Peng, Peersen, Olve B.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159743/
https://ncbi.nlm.nih.gov/pubmed/21722674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2011.06.006
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