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Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase

Positive-strand RNA viruses include a large number of human and animal pathogens whose essential RNA-dependent RNA polymerases (RdRPs) share a structurally homologous core with an encircled active site. RdRPs are targets for antiviral drug development, but these efforts are hindered by limited struc...

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Bibliografske podrobnosti
Main Authors: Gong, Peng, Peersen, Olve B.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012486/
https://ncbi.nlm.nih.gov/pubmed/21148772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007626107
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