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Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase

Positive-strand RNA viruses include a large number of human and animal pathogens whose essential RNA-dependent RNA polymerases (RdRPs) share a structurally homologous core with an encircled active site. RdRPs are targets for antiviral drug development, but these efforts are hindered by limited struc...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Gong, Peng, Peersen, Olve B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2010
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012486/
https://ncbi.nlm.nih.gov/pubmed/21148772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007626107
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