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Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation

Viral RNA-dependent RNA polymerases (RdRPs) play essential roles in viral genome replication and transcription. We previously reported several structural states of the poliovirus RdRP nucleotide addition cycle (NAC) that revealed a unique palm domain-based active site closure mechanism and proposed...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Shu, Bo, Gong, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948327/
https://ncbi.nlm.nih.gov/pubmed/27339134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602591113
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