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Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures

Each polymerase nucleotide addition cycle is associated with two primary conformational changes of the catalytic complex: the pre-chemistry active site closure and post-chemistry translocation. While active site closure is well interpreted by numerous crystallographic snapshots, translocation interm...

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Publicado en:Nat Commun
Autores principales: Wang, Meihua, Li, Rui, Shu, Bo, Jing, Xuping, Ye, Han-Qing, Gong, Peng
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7248106/
https://ncbi.nlm.nih.gov/pubmed/32451382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16234-4
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