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Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase
Positive-strand RNA viruses include a large number of human and animal pathogens whose essential RNA-dependent RNA polymerases (RdRPs) share a structurally homologous core with an encircled active site. RdRPs are targets for antiviral drug development, but these efforts are hindered by limited struc...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3012486/ https://ncbi.nlm.nih.gov/pubmed/21148772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007626107 |
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