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Structures of Coxsackievirus, Rhinovirus, and Poliovirus Polymerase Elongation Complexes Solved by Engineering RNA Mediated Crystal Contacts

RNA-dependent RNA polymerases play a vital role in the growth of RNA viruses where they are responsible for genome replication, but do so with rather low fidelity that allows for the rapid adaptation to different host cell environments. These polymerases are also a target for antiviral drug developm...

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Bibliografski detalji
Glavni autori: Gong, Peng, Kortus, Matthew G., Nix, Jay C., Davis, Ralph E., Peersen, Olve B.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648537/
https://ncbi.nlm.nih.gov/pubmed/23667424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060272
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