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ATP IS AN ALLOSTERIC INHIBITOR OF COXSACKIEVIRUS B3 POLYMERASE
The RNA-dependent RNA polymerases from positive strand RNA viruses, such as picornaviruses and flaviviruses, close their active sites for catalysis via a unique NTP-induced conformational change in the palm domain. Combined with a fully pre-positioned templating nucleotide, this mechanism is error-p...
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| Publicat a: | Biochemistry |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5749642/ https://ncbi.nlm.nih.gov/pubmed/27319576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00467 |
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