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ATP IS AN ALLOSTERIC INHIBITOR OF COXSACKIEVIRUS B3 POLYMERASE
The RNA-dependent RNA polymerases from positive strand RNA viruses, such as picornaviruses and flaviviruses, close their active sites for catalysis via a unique NTP-induced conformational change in the palm domain. Combined with a fully pre-positioned templating nucleotide, this mechanism is error-p...
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| Gepubliceerd in: | Biochemistry |
|---|---|
| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5749642/ https://ncbi.nlm.nih.gov/pubmed/27319576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00467 |
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