Amiloride Is a Competitive Inhibitor of Coxsackievirus B3 RNA Polymerase

Amiloride and its derivative 5-(N-ethyl-N-isopropyl)amiloride (EIPA) were previously shown to inhibit coxsackievirus B3 (CVB3) RNA replication in cell culture, with two amino acid substitutions in the viral RNA-dependent RNA polymerase 3D(pol) conferring partial resistance of CVB3 to these compounds...

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Main Authors: Gazina, Elena V., Smidansky, Eric D., Holien, Jessica K., Harrison, David N., Cromer, Brett A., Arnold, Jamie J., Parker, Michael W., Cameron, Craig E., Petrou, Steven
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2011
Ábhair:
Vaccines and Antiviral Agents
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196452/
https://ncbi.nlm.nih.gov/pubmed/21795353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05022-11
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