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Amiloride Is a Competitive Inhibitor of Coxsackievirus B3 RNA Polymerase
Amiloride and its derivative 5-(N-ethyl-N-isopropyl)amiloride (EIPA) were previously shown to inhibit coxsackievirus B3 (CVB3) RNA replication in cell culture, with two amino acid substitutions in the viral RNA-dependent RNA polymerase 3D(pol) conferring partial resistance of CVB3 to these compounds...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3196452/ https://ncbi.nlm.nih.gov/pubmed/21795353 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05022-11 |
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