Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer

Employing in vitro selection techniques, we have generated biostable RNA-based compounds, so-called Spiegelmers, that specifically bind n-octanoyl ghrelin, the recently discovered endogenous ligand for the type 1a growth hormone secretagogue (GHS) receptor. Ghrelin is a potent stimulant of growth ho...

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Autori principali: Helmling, Steffen, Maasch, Christian, Eulberg, Dirk, Buchner, Klaus, Schröder, Werner, Lange, Christian, Vonhoff, Stefan, Wlotzka, Britta, Tschöp, Matthias H., Rosewicz, Stefan, Klussmann, Sven
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC516544/
https://ncbi.nlm.nih.gov/pubmed/15329412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404175101
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