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An l-RNA-based aquaretic agent that inhibits vasopressin in vivo

A class of diuretic/aquaretic agents based on mirror-image oligonucleotides (so-called Spiegelmers) has been identified. These molecules directly bind and inhibit the neuropeptide vasopressin (AVP). AVP is the major regulatory component of body fluid homeostasis mediated through binding to the renal...

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Bibliografiska uppgifter
Huvudupphovsmän: Purschke, Werner G., Eulberg, Dirk, Buchner, Klaus, Vonhoff, Stefan, Klussmann, Sven
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2006
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458813/
https://ncbi.nlm.nih.gov/pubmed/16547136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509663103
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