SDF-1 inhibition targets the bone marrow niche for cancer therapy

Bone marrow (BM) metastasis remains one of the main causes of death associated with solid tumors as well as with Multiple Myeloma (MM). Targeting the BM niche to prevent or modulate metastasis has not been successful to date. Here we show that stromal cell derived factor-1 (SDF-1/CXCL12) is highly e...

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Autors principals: Roccaro, Aldo M., Sacco, Antonio, Purschke, Werner G., Moschetta, Michele, Buchner, Klaus, Maasch, Christian, Zboralski, Dirk, Zöllner, Stefan, Vonhoff, Stefan, Mishima, Yuji, Maiso, Patricia, Reagan, Michaela R., Lonardi, Silvia, Ungari, Marco, Facchetti, Fabio, Eulberg, Dirk, Kruschinski, Anna, Vater, Axel, Rossi, Giuseppe, Klussmann, Sven, Ghobrial, Irene M.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4194173/
https://ncbi.nlm.nih.gov/pubmed/25263552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.08.042
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