De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination

Activation-induced cytidine deaminase is required for the DNA cleavage step of Ig class switch recombination (CSR). However, its molecular mechanism is controversial. RNA-editing hypothesis postulates that activation-induced cytidine deaminase deaminates cytosine in an unknown mRNA to generate a new...

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Detalhes bibliográficos
Main Authors: Begum, Nasim A., Kinoshita, Kazuo, Muramatsu, Masamichi, Nagaoka, Hitoshi, Shinkura, Reiko, Honjo, Tasuku
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC516508/
https://ncbi.nlm.nih.gov/pubmed/15317942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405219101
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