Negative regulation of activation-induced cytidine deaminase in B cells

Both class switch recombination (CSR) and somatic hypermutation (SHM) of the Ig genes require the activity of activation-induced cytidine deaminase (AID). Expression of AID is restricted to B cells in the germinal centers of the lymphoid organs, where activated B cells undergo CSR and SHM. We previo...

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Bibliographische Detailangaben
Hauptverfasser: Muto, Taro, Okazaki, Il-mi, Yamada, Shuichi, Tanaka, Yoshimasa, Kinoshita, Kazuo, Muramatsu, Masamichi, Nagaoka, Hitoshi, Honjo, Tasuku
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1413812/
https://ncbi.nlm.nih.gov/pubmed/16477013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510970103
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