A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression

Activation-induced cytidine deaminase (AID) is essential for somatic hypermutations (SHM) and class switch recombination. Overexpression of AID in non-B cells can induce SHM in artificial constructs inserted in various loci in the genome. AID overexpression was thus proposed to introduce mutations i...

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Detalhes bibliográficos
Main Authors: Kotani, Ai, Okazaki, Il-mi, Muramatsu, Masamichi, Kinoshita, Kazuo, Begum, Nasim A., Nakajima, Toshiharu, Saito, Hirohisa, Honjo, Tasuku
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC555529/
https://ncbi.nlm.nih.gov/pubmed/15767564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500830102
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