Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice

Activation-induced cytidine deaminase (AID), which is essential to both class switch recombination and somatic hypermutation of the Ig gene, is expressed in many types of human B cell lymphoma/leukemia. AID is a potent mutator because it is involved in DNA breakage not only of Ig but also of other g...

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Detalhes bibliográficos
Main Authors: Kotani, Ai, Kakazu, Naoki, Tsuruyama, Tatsuaki, Okazaki, Il-mi, Muramatsu, Masamichi, Kinoshita, Kazuo, Nagaoka, Hitoshi, Yabe, Daisuke, Honjo, Tasuku
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1785248/
https://ncbi.nlm.nih.gov/pubmed/17251349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610732104
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