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Negative regulation of activation-induced cytidine deaminase in B cells
Both class switch recombination (CSR) and somatic hypermutation (SHM) of the Ig genes require the activity of activation-induced cytidine deaminase (AID). Expression of AID is restricted to B cells in the germinal centers of the lymphoid organs, where activated B cells undergo CSR and SHM. We previo...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1413812/ https://ncbi.nlm.nih.gov/pubmed/16477013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510970103 |
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