PKC-θ knockout mice are protected from fat-induced insulin resistance

Insulin resistance plays a primary role in the development of type 2 diabetes and may be related to alterations in fat metabolism. Recent studies have suggested that local accumulation of fat metabolites inside skeletal muscle may activate a serine kinase cascade involving protein kinase C–θ (PKC-θ)...

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Hlavní autoři: Kim, Jason K., Fillmore, Jonathan J., Sunshine, Mary Jean, Albrecht, Bjoern, Higashimori, Takamasa, Kim, Dong-Wook, Liu, Zhen-Xiang, Soos, Timothy J., Cline, Gary W., O’Brien, William R., Littman, Dan R., Shulman, Gerald I.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2004
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC516267/
https://ncbi.nlm.nih.gov/pubmed/15372106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200422230
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