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Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake

Deletion of acetyl CoA carboxylase-2 (Acc2) reportedly causes leanness in the setting of hyperphagia. To determine the cellular basis for these effects, we generated a mouse model in which Acc2 can be selectively deleted by the action of Cre recombinase. Deletion of Acc2 from skeletal muscle, the pr...

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Hlavní autoři: Olson, David P., Pulinilkunnil, Thomas, Cline, Gary W., Shulman, Gerald I., Lowell, Bradford B.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867727/
https://ncbi.nlm.nih.gov/pubmed/20368432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913492107
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