A model of somatic hypermutation targeting in mice based on high-throughput immunoglobulin sequencing data

Analyses of somatic hypermutation (SHM) patterns in B-cell immunoglobulin (Ig) sequences have important basic science and clinical applications, but are often confounded by the intrinsic biases of SHM targeting on specific DNA motifs (i.e., hot- and cold-spots). Modeling these biases has been hinder...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Immunol
Prif Awduron: Cui, Ang, Di Niro, Roberto, Vander Heiden, Jason A., Briggs, Adrian W., Adams, Kris, Gilbert, Tamara, O'Connor, Kevin C., Vigneault, Francois, Shlomchik, Mark J., Kleinstein, Steven H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161250/
https://ncbi.nlm.nih.gov/pubmed/27707999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1502263
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