Models of Somatic Hypermutation Targeting and Substitution Based on Synonymous Mutations from High-Throughput Immunoglobulin Sequencing Data

Analyses of somatic hypermutation (SHM) patterns in B cell immunoglobulin (Ig) sequences contribute to our basic understanding of adaptive immunity, and have broad applications not only for understanding the immune response to pathogens, but also to determining the role of SHM in autoimmunity and B...

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Detalhes bibliográficos
Main Authors: Yaari, Gur, Vander Heiden, Jason A., Uduman, Mohamed, Gadala-Maria, Daniel, Gupta, Namita, Stern, Joel N. H., O’Connor, Kevin C., Hafler, David A., Laserson, Uri, Vigneault, Francois, Kleinstein, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828525/
https://ncbi.nlm.nih.gov/pubmed/24298272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00358
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