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Somatic hypermutation targeting is influenced by location within the Immunoglobulin V region
The observed mutation pattern in Immunoglobulin V genes is influenced by several mechanisms, including AID targeting to DNA motifs (hot spots), negative selection of B cells that accumulate mutations that prevent the expression of the Ig receptor, and positive selection of B cells that carry affinit...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3109224/ https://ncbi.nlm.nih.gov/pubmed/21592579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2011.04.002 |
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