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Position-dependent Differential Targeting of Somatic Hypermutation
Somatic hypermutation (SHM) generates much of the antibody diversity necessary for affinity maturation and effective humoral immunity. The AID-induced DNA lesions and error-prone repair that underlie SHM are known to exhibit intrinsic biases when targeting the immunoglobulin (Ig) sequences. Computat...
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| Publicado no: | J Immunol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7726104/ https://ncbi.nlm.nih.gov/pubmed/33188076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.2000496 |
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