The STIM1-binding site nexus remotely controls Orai1 channel gating

The ubiquitously expressed Orai Ca(2+) channels are gated through a unique process of intermembrane coupling with the Ca(2+)-sensing STIM proteins. Despite the significance of Orai1-mediated Ca(2+) signals, how gating of Orai1 is triggered by STIM1 remains unknown. A widely held gating model invokes...

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Udgivet i:Nat Commun
Main Authors: Zhou, Yandong, Cai, Xiangyu, Loktionova, Natalia A., Wang, Xianming, Nwokonko, Robert M., Wang, Xizhuo, Wang, Youjun, Rothberg, Brad S., Trebak, Mohamed, Gill, Donald L.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155162/
https://ncbi.nlm.nih.gov/pubmed/27929067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13725
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