Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site

STIM1 and STIM2 are widely expressed endoplasmic reticulum (ER) Ca(2+) sensor proteins able to translocate within the ER membrane to physically couple with and gate plasma membrane Orai Ca(2+) channels. Although structurally similar, we reveal critical differences in the function of the short STIM-O...

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Hauptverfasser: Wang, Xizhuo, Wang, Youjun, Zhou, Yandong, Hendron, Eunan, Mancarella, Salvatore, Andrake, Mark D., Rothberg, Brad S., Soboloff, Jonathan, Gill, Donald L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3995141/
https://ncbi.nlm.nih.gov/pubmed/24492416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4183
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