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Distinct Orai-coupling domains in STIM1 and STIM2 define the Orai-activating site
STIM1 and STIM2 are widely expressed endoplasmic reticulum (ER) Ca(2+) sensor proteins able to translocate within the ER membrane to physically couple with and gate plasma membrane Orai Ca(2+) channels. Although structurally similar, we reveal critical differences in the function of the short STIM-O...
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| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3995141/ https://ncbi.nlm.nih.gov/pubmed/24492416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4183 |
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