Cross-linking of Orai1 channels by STIM proteins

The transmembrane docking of endoplasmic reticulum (ER) Ca(2+)-sensing STIM proteins with plasma membrane (PM) Orai Ca(2+) channels is a critical but poorly understood step in Ca(2+) signal generation. STIM1 protein dimers unfold to expose a discrete STIM–Orai activating region (SOAR1) that tethers...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Zhou, Yandong, Nwokonko, Robert M., Cai, Xiangyu, Loktionova, Natalia A., Abdulqadir, Raz, Xin, Ping, Niemeyer, Barbara A., Wang, Youjun, Trebak, Mohamed, Gill, Donald L.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5899466/
https://ncbi.nlm.nih.gov/pubmed/29581306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1720810115
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