STIM1 dimers undergo unimolecular coupling to activate Orai1 channels

The endoplasmic reticulum (ER) Ca(2+) sensor, STIM1, becomes activated when ER-stored Ca(2+) is depleted and translocates into ER–plasma membrane junctions where it tethers and activates Orai1 Ca(2+) entry channels. The dimeric STIM1 protein contains a small STIM-Orai-activating region (SOAR)—the mi...

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Publicat a:Nat Commun
Autors principals: Zhou, Yandong, Wang, Xizhuo, Wang, Xianming, Loktionova, Natalia A., Cai, Xiangyu, Nwokonko, Robert M., Vrana, Erin, Wang, Youjun, Rothberg, Brad S., Gill, Donald L.
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598629/
https://ncbi.nlm.nih.gov/pubmed/26399906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9395
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