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Pore properties of Orai1 calcium channel dimers and their activation by the STIM1 ER calcium sensor

Store-operated Ca(2+) entry signals are mediated by plasma membrane Orai channels activated through intermembrane coupling with Ca(2+)-sensing STIM proteins in the endoplasmic reticulum (ER). The nature of this elaborate Orai-gating mechanism has remained enigmatic. Based on the Drosophila Orai stru...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Cai, Xiangyu, Nwokonko, Robert M., Loktionova, Natalia A., Abdulqadir, Raz, Baraniak, James H., Wang, Youjun, Trebak, Mohamed, Zhou, Yandong, Gill, Donald L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2018
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102135/
https://ncbi.nlm.nih.gov/pubmed/29954946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003424
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