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Hypoxia and defective apoptosis drive genomic instability and tumorigenesis

Genomic instability is a hallmark of cancer development and progression, and characterizing the stresses that create and the mechanisms by which cells respond to genomic perturbations is essential. Here we demonstrate that antiapoptotic BCL-2 family proteins promoted tumor formation of transformed b...

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Autori principali: Nelson, Deirdre A., Tan, Ting-Ting, Rabson, Arnold B., Anderson, Diana, Degenhardt, Kurt, White, Eileen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC515288/
https://ncbi.nlm.nih.gov/pubmed/15314031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1204904
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