Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis

DNA polymerase ε (POLE) is a four-subunit complex and the major leading strand polymerase in eukaryotes. Budding yeast orthologs of POLE3 and POLE4 promote Polε processivity in vitro but are dispensable for viability in vivo. Here, we report that POLE4 deficiency in mice destabilizes the entire Polε...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell
Asıl Yazarlar: Bellelli, Roberto, Borel, Valerie, Logan, Clare, Svendsen, Jennifer, Cox, Danielle E., Nye, Emma, Metcalfe, Kay, O’Connell, Susan M., Stamp, Gordon, Flynn, Helen R., Snijders, Ambrosius P., Lassailly, François, Jackson, Andrew, Boulton, Simon J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cell Press 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972231/
https://ncbi.nlm.nih.gov/pubmed/29754823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.04.008
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