Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis

DNA polymerase ε (POLE) is a four-subunit complex and the major leading strand polymerase in eukaryotes. Budding yeast orthologs of POLE3 and POLE4 promote Polε processivity in vitro but are dispensable for viability in vivo. Here, we report that POLE4 deficiency in mice destabilizes the entire Polε...

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Publicat a:Mol Cell
Autors principals: Bellelli, Roberto, Borel, Valerie, Logan, Clare, Svendsen, Jennifer, Cox, Danielle E., Nye, Emma, Metcalfe, Kay, O’Connell, Susan M., Stamp, Gordon, Flynn, Helen R., Snijders, Ambrosius P., Lassailly, François, Jackson, Andrew, Boulton, Simon J.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5972231/
https://ncbi.nlm.nih.gov/pubmed/29754823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.04.008
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