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Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis
DNA polymerase ε (POLE) is a four-subunit complex and the major leading strand polymerase in eukaryotes. Budding yeast orthologs of POLE3 and POLE4 promote Polε processivity in vitro but are dispensable for viability in vivo. Here, we report that POLE4 deficiency in mice destabilizes the entire Polε...
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| Yayımlandı: | Mol Cell |
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| Asıl Yazarlar: | , , , , , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Cell Press
2018
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5972231/ https://ncbi.nlm.nih.gov/pubmed/29754823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.04.008 |
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