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2A4 binds soluble and insoluble light chain aggregates from AL amyloidosis patients and promotes clearance of amyloid deposits by phagocytosis (†)

Amyloid light chain (AL) amyloidosis is characterized by misfolded light chain (LC) (amyloid) deposition in various peripheral organs, leading to progressive dysfunction and death. There are no regulatory agency–approved treatments for AL amyloidosis, and none of the available standard of care appro...

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Détails bibliographiques
Publié dans:Amyloid
Auteurs principaux: Renz, Mark, Torres, Ronald, Dolan, Philip J., Tam, Stephen J., Tapia, Jose R., Li, Lauri, Salmans, Joshua R., Barbour, Robin M., Shughrue, Paul J., Nijjar, Tarlochan, Schenk, Dale, Kinney, Gene G., Zago, Wagner
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5152553/
https://ncbi.nlm.nih.gov/pubmed/27494229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/13506129.2016.1205974
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