Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin

Introduction: Transthyretin amyloidosis (ATTR amyloidosis) is caused by the misfolding and deposition of the transthyretin (TTR) protein and results in progressive multi-organ dysfunction. TTR epitopes exposed by dissociation and misfolding are targets for immunotherapeutic antibodies. We developed...

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Detalhes bibliográficos
Publicado no:Amyloid
Main Authors: Higaki, Jeffrey N., Chakrabartty, Avi, Galant, Natalie J., Hadley, Kevin C., Hammerson, Bradley, Nijjar, Tarlochan, Torres, Ronald, Tapia, Jose R., Salmans, Joshua, Barbour, Robin, Tam, Stephen J., Flanagan, Ken, Zago, Wagner, Kinney, Gene G.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4898150/
https://ncbi.nlm.nih.gov/pubmed/26981744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/13506129.2016.1148025
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