Novel conformation-specific monoclonal antibodies against amyloidogenic forms of transthyretin

Introduction: Transthyretin amyloidosis (ATTR amyloidosis) is caused by the misfolding and deposition of the transthyretin (TTR) protein and results in progressive multi-organ dysfunction. TTR epitopes exposed by dissociation and misfolding are targets for immunotherapeutic antibodies. We developed...

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Dades bibliogràfiques
Publicat a:Amyloid
Autors principals: Higaki, Jeffrey N., Chakrabartty, Avi, Galant, Natalie J., Hadley, Kevin C., Hammerson, Bradley, Nijjar, Tarlochan, Torres, Ronald, Tapia, Jose R., Salmans, Joshua, Barbour, Robin, Tam, Stephen J., Flanagan, Ken, Zago, Wagner, Kinney, Gene G.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2016
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4898150/
https://ncbi.nlm.nih.gov/pubmed/26981744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/13506129.2016.1148025
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