Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors

[Image: see text] Mer tyrosine kinase (MerTK) is aberrantly elevated in various tumor cells and has a normal anti-inflammatory role in the innate immune system. Inhibition of MerTK may provide dual effects against these MerTK-expressing tumors through reducing cancer cell survival and redirecting th...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: Wang, Xiaodong, Liu, Jing, Zhang, Weihe, Stashko, Michael A., Nichols, James, Miley, Michael J., Norris-Drouin, Jacqueline, Chen, Zhilong, Machius, Mischa, DeRyckere, Deborah, Wood, Edgar, Graham, Douglas K., Earp, H. Shelton, Kireev, Dmitri, Frye, Stephen V.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2016
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5151143/
https://ncbi.nlm.nih.gov/pubmed/27994735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00221
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