Possible catalytic activity of DNA in the reaction between the antitumor drug cis-diamminedichloroplatinum(II) and the intercalator N-methyl-2,7-diazapyrenium.

The platinum(II) complex cis-[Pt(NH3)2(N7-N-methyl-2-diazapyrenium)Cl]2+ formed in the reaction between cis-diamminedichloroplatinum(II) and N-methyl-2,7-diazapyrenium reacts with N7 of guanine residues in DNA. The resulting adduct is kinetically inert within single-stranded DNA. Within double-stran...

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Gaucheron, F, Malinge, J M, Blacker, A J, Lehn, J M, Leng, M
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1991
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51482/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2023897/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.9.3516
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