Possible catalytic activity of DNA in the reaction between the antitumor drug cis-diamminedichloroplatinum(II) and the intercalator N-methyl-2,7-diazapyrenium.

The platinum(II) complex cis-[Pt(NH3)2(N7-N-methyl-2-diazapyrenium)Cl]2+ formed in the reaction between cis-diamminedichloroplatinum(II) and N-methyl-2,7-diazapyrenium reacts with N7 of guanine residues in DNA. The resulting adduct is kinetically inert within single-stranded DNA. Within double-stran...

Fuld beskrivelse

Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Gaucheron, F, Malinge, J M, Blacker, A J, Lehn, J M, Leng, M
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1991
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51482/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2023897/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.9.3516
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!