Structural Basis for Selective Interaction between the ESCRT Regulator HD-PTP and UBAP1

Endosomal sorting complexes required for transport (ESCRTs) are essential for ubiquitin-dependent degradation of mitogenic receptors, a process often compromised in cancer pathologies. Sorting of ubiquinated receptors via ESCRTs is controlled by the tumor suppressor phosphatase HD-PTP. The specific...

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Publicat a:Structure
Autors principals: Gahloth, Deepankar, Levy, Colin, Heaven, Graham, Stefani, Flavia, Wunderley, Lydia, Mould, Paul, Cliff, Matthew J., Bella, Jordi, Fielding, Alistair J., Woodman, Philip, Tabernero, Lydia
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5145805/
https://ncbi.nlm.nih.gov/pubmed/27839950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.10.006
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