Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed ubiquitously throughout the brain, where they function to regulate the excitability of neurons. The subcellular distribution of these channels in pyramidal neurons of hippocampal area CA1 is regulated by tetratricopepti...

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Bibliographische Detailangaben
Veröffentlicht in:J Vis Exp
Hauptverfasser: Han, Ye, Lyman, Kyle A., Clutter, Matt, Schiltz, Gary E., Ismail, Quratul-Ain, Cheng, Xiangying, Luan, Chi-Hao, Chetkovich, Dane M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MyJove Corporation 2016
Schlagworte:
Biochemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5145243/
https://ncbi.nlm.nih.gov/pubmed/27911380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/54540
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