Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels

Tetratricopeptide repeat (TPR) domains are ubiquitous structural motifs that mediate protein–protein interactions. For example, the TPR domains in the peroxisomal import receptor PEX5 enable binding to a range of type 1 peroxisomal targeting signal motifs. A homolog of PEX5, tetratricopeptide repeat...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Lyman, Kyle A., Han, Ye, Heuermann, Robert J., Cheng, Xiangying, Kurz, Jonathan E., Lyman, Reagan E., Van Veldhoven, Paul P., Chetkovich, Dane M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Neurobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663874/
https://ncbi.nlm.nih.gov/pubmed/28887304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.802256
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