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HCN channel dendritic targeting requires bipartite interaction with TRIP8b and regulates antidepressant-like behavioral effects

Major Depressive Disorder is a prevalent psychiatric condition with limited therapeutic options beyond monoaminergic therapies. Although effective in some individuals, many patients fail to respond adequately to existing treatments and new pharmacologic targets are needed. HCN channels regulate exci...

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Bibliografiske detaljer
Udgivet i:Mol Psychiatry
Main Authors: Han, Ye, Heuermann, Robert J., Lyman, Kyle A., Fisher, Daniel, Ismail, Quratul-Ain, Chetkovich, Dane M.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5233690/
https://ncbi.nlm.nih.gov/pubmed/27400855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2016.99
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