HCN channel dendritic targeting requires bipartite interaction with TRIP8b and regulates antidepressant-like behavioral effects

Major Depressive Disorder is a prevalent psychiatric condition with limited therapeutic options beyond monoaminergic therapies. Although effective in some individuals, many patients fail to respond adequately to existing treatments and new pharmacologic targets are needed. HCN channels regulate exci...

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Bibliographic Details
Published in:Mol Psychiatry
Main Authors: Han, Ye, Heuermann, Robert J., Lyman, Kyle A., Fisher, Daniel, Ismail, Quratul-Ain, Chetkovich, Dane M.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5233690/
https://ncbi.nlm.nih.gov/pubmed/27400855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2016.99
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