Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are expressed ubiquitously throughout the brain, where they function to regulate the excitability of neurons. The subcellular distribution of these channels in pyramidal neurons of hippocampal area CA1 is regulated by tetratricopepti...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Vis Exp
Prif Awduron: Han, Ye, Lyman, Kyle A., Clutter, Matt, Schiltz, Gary E., Ismail, Quratul-Ain, Cheng, Xiangying, Luan, Chi-Hao, Chetkovich, Dane M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MyJove Corporation 2016
Pynciau:
Biochemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5145243/
https://ncbi.nlm.nih.gov/pubmed/27911380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/54540
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