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Phosphorylation of the HCN channel auxiliary subunit TRIP8b is altered in an animal model of temporal lobe epilepsy and modulates channel function

Temporal lobe epilepsy (TLE) is a prevalent neurological disorder with many patients experiencing poor seizure control with existing anti-epileptic drugs. Thus, novel insights into the mechanisms of epileptogenesis and identification of new drug targets can be transformative. Changes in ion channel...

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Publicat a:J Biol Chem
Autors principals: Foote, Kendall M., Lyman, Kyle A., Han, Ye, Michailidis, Ioannis E., Heuermann, Robert J., Mandikian, Danielle, Trimmer, James S., Swanson, Geoffrey T., Chetkovich, Dane M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816094/
https://ncbi.nlm.nih.gov/pubmed/31492750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010027
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